• In silico docking analysis performed in the current study in

  2023-11-29

  

  In silico docking analysis performed in the current study indicated that TCDD strongly binds to AhR-LBD. Moreover, the formation of the TCDD/AhR-LBD complex was confirmed experimentally with the use of EMSA. We found that 10nM TCDD after 2 hours of incubation not only bound to the AhR in the porcine

• Adiponectin also works on AdipoR inducing extracellular Ca i

  2023-11-29

  

  Adiponectin also works on AdipoR1, inducing extracellular Ca2+ influx necessary for activation of Ca2+/calmodulin-dependent protein kinase kinase (CaMKK)β, AMPK (Fig. 1). This step is then followed by activation of SirT1 and increased expression and decreased acetylation of PPARγ coactivator (PGC)-1

• Active SI behavior was dose dependently affected by PACAP

  2023-11-29

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p Kif15-IN-1 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.

• Introduction Pyometra is relatively common in intact bitches

  2023-11-29

  

  Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor

• br Acknowledgement br Introduction There has been great prog

  2023-11-29

  

  Acknowledgement Introduction There has been great progress in the treatment of autoimmune disease during the past several decades. However, the majority of autoimmune diseases have no known cure. B lymphocytes and autoantibodies play important roles in many autoimmune diseases, including rheum

• br Materials and methods br

  2023-11-29

  

  Materials and methods Results Discussion Many studies investigate the role of 12/15-LOX in cancer cell,23, 24, 25 however we here first found that host 12/15-LOX also plays an important role in metastasis progression. We have demonstrated that 12(S)-HETE increased melanoma cell adhesion to

• In order to determine whether the faster

  2023-11-28

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in 2365 depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to cholest

• br Results and discussion This paper reports the

  2023-11-28

  

  Results and discussion This paper reports the synthesis of methoxy and 4-thio derivatives of quercetin and luteolin, which includes two new derivatives (4 and 12) and explores how subtle variations in the chemical structure of flavonoids affect their biological activity, particularly in relation

• br Materials and methods br Results br Discussion

  2023-11-28

  

  Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic PF 04418948 sale [30]

• Interestingly metabolic dysfunction is also observed in amyo

  2023-11-28

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting vesicular monoamine transporter expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) foun

• br Acknowledgements This work was supported by Programme Gra

  2023-11-28

  

  Acknowledgements This work was supported by Programme Grants from the MRC and the Wellcome Trust (SGC-C and MF). CB was in receipt of a Marie Curie Intra-European Fellowship during part of this work. We thank past and present members of our group for numerous valuable discussions throughout these

• Further validation for a role

  2023-11-28

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

• About this report Alzheimer s Disease Facts and Figures is

  2023-11-28

  

  About this report 2018 Alzheimer's Disease Facts and Figures is a statistical resource for U.S. data related to Alzheimer's disease, the most common cause of dementia. Background and context for interpreting the data are contained in the Overview. Additional sections address prevalence, mortality a

• br Conflict of interest br

  2023-11-28

  

  Conflict of interest Introduction Colorectal cancer (CRC) is one of the major cause of tumor-related morbidity and mortality worldwide. Poor prognosis and consequences of its metastatic spread make CRC the second most common cause of cancer-related deaths in western countries [1]. Apart from o

• br There is evidence to

  2023-11-28

  

  There is evidence to suggest that GMF activities are regulated in vivo by post-translational modification. indeed, there is strong precedent for ADF-homology family proteins being regulated in this manner. Cofilin is inhibited by phosphorylation of a serine residue at its N terminus. This residue

14209 records 196/948 page Previous Next First page 上5页 196197198199200 下5页 Last page