• We demonstrated clearly that the overexpression of sFlt sign

  2023-08-22

  

  We demonstrated clearly that the overexpression of sFlt-1 significantly increased arginase dopamine receptors and enhanced arginase activity in HUVECs (Fig. 3). NO formation is related inversely to serum levels of sFlt-1 in preeclampsia [11]. The disorder of NO formation, which was involved in hype

• br APJ expression in metabolic

  2023-08-22

  

  APJ expression in metabolic diseases Under physiological conditions, APJ is present in humans as well as in mouse tissues with high metabolic activity such as muscle and adipose tissue but not in the liver. Moreover, the presence and regulation of APJ in established adipocyte or muscle cell lines

• br Metabolic effects of apelin in obesity and

  2023-08-22

  

  Metabolic effects of apelin in obesity and type 2 diabetes Mice fed a high fat diet (HFD) for several weeks become obese, hyperglycemic, hyperinsulinemic and insulin resistant. Acute apelin treatment by intravenous injection or by infusion during a hyperinsulinemic–euglycemic clamp in obese and i

• br Author Contributions br Acknowledgments br Introduction

  2023-08-22

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to Amikacin mg tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic

• br MHCI peptide editing N terminal extensions and the

  2023-08-22

  

  MHCI peptide editing, N-terminal extensions and the peptide loading complex Conventionally, peptide-MHCI binding is thought to require both amino- and carboxyl-termini for stable interaction (Madden, 1995; Bouvier and Wiley, 1994). Peptides with longer than optimal length (10–13 residues) have be

• Further evidence for action mechanism was provided by assays

  2023-08-21

  

  Further evidence for action mechanism was provided by assays using [3H]nisoxetine, a selective NET inhibitor used as standard radioligand for competitive binding experiments. The results showed dose-dependent blocking of [3H]nisoxetine binding by both xylazine and dexmedetomidine. Nisoxetine binds t

• Changes in actin microfilaments are mediated

  2023-08-21

  

  Changes in fasudil microfilaments are mediated by changes in extracellular matrix, mechanical stimulation or growth factors intracellular signaling. We observed significant changes in a number of intracellular signaling pathways associated with changes in actin dynamics during hMSCs differentiation

• AP activation is known to upregulate downstream target

  2023-08-21

  

  AP-1 activation is known to upregulate downstream target genes including dopamine-2 receptor antagonist D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, tr

• br Author contributions br Acknowledgments TJC KW

  2023-08-21

  

  Author contributions Acknowledgments TJC, KW, and VG are supported by awards made to MJN: a Consolidator Grant from the European Research Council under Grant no. 311336; a University Research Fellowship from the Royal Society, and a Career Development Award from the Human Frontiers Science Pro

• From an historical perspective ligands for

  2023-08-21

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, ap-1 or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands were rapid

• In addition understanding the relationship between human met

  2023-08-21

  

  In addition, understanding the relationship between human metabolic processes and dietary antioxidant intake would provide opportunities for altering the diet to improve health (Prior, 2015). Prior et al. (2007) emphasized that excess reactive oxygen species, which occurred during the metabolism of

• Formation of SAHFs in human cells

  2023-08-21

  

  Formation of SAHFs in human Fmoc-Ala-OH is a dynamic and multifaceted process that is largely dependent on the p16/pRB ras-induced senescence pathway [108]. Many details remain to be elucidated but formation appears to be driven by a complex of histone chaperones (HIRA and ASF1a), a pRB/hBrm/HDAC1/H

• Indications that HMGA proteins are involved in regulating

  2023-08-21

  

  Indications that HMGA proteins are involved in regulating the structure and function of large chromatin domains come from the early work of Saitoh and Laemmli [143]. Employing immunolocalization techniques, these workers demonstrated that HMGA1 proteins are co-localized with both histone H1 and the

• Several studies have explored the relationship between

  2023-08-21

  

  Several studies have explored the relationship between dental implants and MRONJ development. López-Cedrún JL et al. [13] reported that BRONJ developed after implant treatment in nine patients who were taking bisphosphonates orally. The mean interval between the initiation of treatment and the onset

• In addition to differential expression of AR protein

  2023-08-21

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human Cy5.5 maleimide (non-sulfonated) cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive

14216 records 254/948 page Previous Next First page 上5页 251252253254255 下5页 Last page