• br Discussion This study dedicated to histamine

  2021-09-29

  

  Discussion This study, dedicated to AN-2728 receptor H3 and H4 receptors, was carried out on superfused tissues preincubated with 3H-choline or 3H-noradrenaline; electrical stimulation was used to elicit quasi-physiological exocytotic release of the respective transmitter. Since inhibition of tr

• The electroconductive or electrocatalytic properties of cond

  2021-09-29

  

  The electroconductive or electrocatalytic properties of conductive moieties including polymers in combination with carbon or metal-based nanomaterials have also been explored. For example, Dong et al. (2017) developed a portable electrochemical immunosensor by creating a film of Prussian blue chitos

• br Materials and methods br Results br Discussion

  2021-09-29

  

  Materials and methods Results Discussion Metabolic abnormalities and systemic immune dysfunctions are common during HIV infection and/or antiretroviral therapy. Although some transcriptomic studies of HIV infection have revealed global changes in the mRNA and microRNA expression profiles (R

• Morin is a flavonoid that

  2021-09-29

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• Although we showed that RBL

  2021-09-29

  

  Although we showed that RBL-2H3 Sc98 SC 79 took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including SERT for

• The regulation of the stem cell compartment in CML

  2021-09-29

  

  The regulation of the stem cell compartment in CML is dynamic, in particular, during disease progression to a blast crisis and might involve a complex cross-regulation of Hh, Wnt, Notch, and hox signaling pathways (). Significant upregulation of Ptch1 and cyclin D1, upon other proteins, marks the bl

• br Ghrelin Ghrelin was purified from

  2021-09-28

  

  Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino Loxapine synthesis octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1a is a 7-transmemb

• Glycine released from astrocytes as well as neurons is

  2021-09-28

  

  Glycine released from astrocytes as well as neurons is also known as a co-agonist of NMDAR (Roux and Supplisson, 2000). Neuronal glycine in mouse hippocampus might be released from glutamatergic terminals (Muller et al., 2013) that express functional 5-hme-CTP synthesis receptors (Rodriguez et al.,

• Mammals adapt to prolonged periods of food scarcity by

  2021-09-28

  

  Mammals adapt to prolonged periods of food scarcity by releasing FFAs from adipose tissue and transforming them into energy-rich ketone bodies that are used as fuel by brain, muscle, and other organs (Kersten, 2014, Grabacka et al., 2016). Ketogenesis occurs primarily in hepatocytes, but its rate is

• Several plant derived molecules such

  2021-09-28

  

  Several plant-derived molecules such as resveratrol, curcumin, zerumbone, and physalin B have been reported as modulators of Hh/Gli signaling pathway (Hosoya et al., 2008, Mohapatra et al., 2015). Our previous studies have demonstrated that a sesquiterpene lactone and diarylheptanoids from Siegesbec

• It has been reported that CD

  2021-09-28

  

  It has been reported that CD133+ glioma stem f4 cat are resistant to temozolomide (TMZ) therapy [155]. Dose dependent TMZ treatment of CD133+ cells enhanced activities of the Notch and SHh pathways [156]. Moreover, 500 μmol/L TMZ induced a significant upregulation of Gli1, HES1 and HES5 transcripts

• Annexin A ANXA a member

  2021-09-28

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

• In addition to changes in the Rho isoforms all

  2021-09-28

  

  In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer XL184 receptor (Chan et al.

• br Acknowledgements br Introduction Type diabetes

  2021-09-28

  

  Acknowledgements Introduction Type 2 diabetes is a progressive metabolic disorder which is characterised by chronic hyperglycaemia due to relative insulin deficiency, insulin resistance and increased hepatic glucose production [1]. The metabolism of glucose by glycolysis increases the ATP:ADP

• pexidartinib br Acknowledgments br Introduction Myelin one

  2021-09-28

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the pexidartinib of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC) i

13884 records 494/926 page Previous Next First page 上5页 491492493494495 下5页 Last page