• Furthermore the identification of the inhibitory effect of P

  2021-11-08

  

  Furthermore, the identification of the inhibitory effect of P. grandiflorum and ginseng extract on HDAC represents an effective workflow for gene expression similarity-based repositioning of nutraceuticals. Acknowledgments This research was supported by Basic Science Research Program through the

• Renal disease is characterized by aberrant

  2021-11-08

  

  Renal disease is characterized by aberrant fibrotic remodeling of renal tissue, elevated apoptosis in kidney tissue, and eventual organ failure. In addition, patients with renal disease are more likely to suffer from systemic hypertension due to oxidative damage (reviewed in Ref. [18]). Treatment of

• In addition to redox stress nutritional intake plays a

  2021-11-08

  

  In addition to redox stress, nutritional intake plays a key role in modulating energy metabolism. DIO animal models are commonly used to study altered metabolic changes consequential to fat storage within various fat pads. In general, diets containing >40% high-fat lard, milk, and butter promote exc

• In the present study Trichoderma viride glucosidase was

  2021-11-08

  

  In the present study, Trichoderma viride β-glucosidase was screened in our laboratory and used for the synthesis of gentiooligosaccharides via reverse hydrolysis and transglycosylation. Material and methods Results and discussion Conclusions In the present study, the T. viride β-glucosidas

• SBHA br Vertebrate steroid receptor evolution br

  2021-11-08

  

  Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th

• br Ghrelin Ghrelin was purified from rat stomach

  2021-11-08

  

  Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino vx 809 octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1a is a 7-transmembrane recepto

• Furthermore our results are the first to demonstrate that th

  2021-11-08

  

  Furthermore, our results are the first to demonstrate that the stimulating effect of GALP on AVP release in rats is independent of galanin receptors. The same stimulatory GALP influence on AVP secretion has been also observed in the presence of galantide, an antagonist of Gal receptors in the incuba

• br Future perspectives A plethora

  2021-11-08

  

  Future perspectives A plethora of reports from in vivo and in vitro human and animal studies have demonstrated the potential role of FGFR signalling in human carcinogenesis, whether it be in an oncogenic or tumour suppressive capacity. It is still not well understood how FGFRs can act as tumour s

• Recent research has focused on identifying key

  2021-11-08

  

  Recent research has focused on identifying key agonists and receptors mediating nutrient-induced GLP-1 and insulin secretion. The long-chain fatty SNOG receptor GPR40 is the most abundant GPCR expressed in islet β cells and is also expressed on intestinal L-cells, where it contributes to GLP-1 rele

• Our results are consistent with the hypothesis that reduced

  2021-11-08

  

  Our results are consistent with the hypothesis that reduced Fas-mediated apoptosis in maternally activated T-lymphocytes could result in insufficient trophoblast invasion of the spiral Wnt-C59 as the activated T-lymphocytes become able to enhance the destruction of the cytotrophoblasts. A reduced n

• MMV s distinct mode of inhibition addresses key

  2021-11-08

  

  MMV019313's distinct mode of inhibition addresses key impediments in the development of PfFPPS/GGPPS inhibitors as antimalarial drugs. First, it is the first non-bisphosphonate inhibitor of Plasmodium FPPS/GGPPS with drug-like physicochemical properties satisfying the “Rule of 5” (Van Voorhis et al.

• br Materials and methods br Results br Discussion The

  2021-11-08

  

  Materials and methods Results Discussion The roles of EZH2 during oocyte maturation, early embryogenesis, and somatic cell nucleus transfer (SCNT) have been studied extensively in mouse [12,30]. How it functions during porcine preimplantation development, especially the maternal effect, how

• More recently the JmjC domain histone H K di

  2021-11-08

  

  More recently, the JmjC domain histone H3K36 di-demethylase KDM2B/FBXL10 has also been shown to play an important role in definitive hematopoiesis [17]. Kdm2b is highly expressed in the HE, and its deletion (Tie2) caused embryonic lethality due to a precipitous drop in the number of hemogenic endoth

• The stability and function of the HIF protein are affected

  2021-11-08

  

  The stability and function of the HIF-1α protein are affected by many post-translational modifications (PTMs), including hydroxylation, acetylation, ubiquitination and SUMOylation [[29], [30], [31]]. It has been shown that HIF-1α stability is regulated by LSD1 [25]; in particular, the Set9 histone m

• Although HK localizes mainly to either the

  2021-11-08

  

  Although HK localizes mainly to either the cytosol or mitochondria [29], [30], [31] and cardioprotection is associated with increased mitochondrial HK binding, some studies have identified a component of HK located in intracellular vesicles within the cardiomyocyte [48], [61], supporting older data

14260 records 495/951 page Previous Next First page 上5页 491492493494495 下5页 Last page