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br Acknowledgments This research was supported by grants fro
2021-06-16
Acknowledgments This research was supported by grants from the Ministerio de Ciencia e Innovación (Grants SAF/FEDER 2010-17907; 2013-49076-P), Spain, Red de trastornos adictivos (RETICS RD12/0028//0003, Instituto de Salud Carlos III, Spain) and Fundación Séneca (15405/PI/10, Región de Murcia, Spa
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To date the role of CRF
2021-06-16
To date, the role of CRF and CRF1+ neurons within the amygdala in the expression of anxiety-like behavior and conditioned fear, and the place where these cell populations fit into the fear-related microcircuitry already identified in the CeA, have not been fully characterized. Recent evidence suppor
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TR provides requirements for qualification of commercial
2021-06-16
TR-107330 (1996) provides requirements for qualification of commercial PLC. It uses the criteria of NUREG/CR-6421. EPRI TR-104159 (1995) includes experience about dedicating COTS SW for PLC-based digital systems such as DAFAS (Diverse Auxiliary Feedwater Actuation System) and Emergency Diesel Bus Lo
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Although CK phosphorylated Msn as well as
2021-06-16
Although CK2 phosphorylated Msn4 as well as Msn2 (Fig. 1A), the two CK2-dependent phosphorylation sites in Msn2 are not conserved in Msn4. Thus, Msn2 and Msn4 might be differently regulated by CK2-dependent phosphorylation. Msn2 and Msn4, which have 41% identity and similarity in size and amino Gris
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Introduction Obesity constitutes a global healthcare problem
2021-06-15
Introduction Obesity constitutes a global healthcare problem and has many adverse effects on the cardiovascular function [1,2]. Recently, the perivascular adipose tissue (PVAT) has emerged as a relevant fat depot for cardiovascular risk and as a potential trigger in vascular dysfunction. Indeed, PV
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In terms of its protease activity
2021-06-15
In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other Nifedipine of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade the insulin
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Collagen type is the most abundant extracellular matrix ECM
2021-06-15
Collagen type 1 is the most abundant extracellular matrix (ECM) protein found in vertebrates. Collagen exerts its role as a load bearing structure and regulator of cell function, only after it has assembled into fibrils., The equilibrium between the synthesis and degradation of collagen fibrils and
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In this report we describe studies of the effects of
2021-06-15
In this report we describe studies of the effects of peroxisome proliferator-activated receptor γ (PPARγ) and acyl-CoA synthetase (ACSL1) on palmitate-induced ER stress in the human cardiomyocyte-like cell line AC16 [22], which was derived from adult ventricular heart tissue. PPARγ is a nuclear rece
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Polymorphism of the CD gene also affected the progression
2021-06-15
Polymorphism of the CD226 gene also affected the progression rate without any significant effect on autoantibody formation. This gene has been reported to be a common genetic factor in multiple autoimmune diseases such as SLE, systemic sclerosis and type 1 diabetes [43]. CD226 is an immunoglobulin s
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DUBs are involved in cell
2021-06-15
DUBs are involved in acetylcholinesterase inhibitor regulation and DNA damage pathways and since, in cancer and different stress conditions all the proteins which regulate cell cycle and DNA damage/repair are either up/down regulated (Singh et al., 2013, Singh et al., 2011, Kumar and de Massy, 2010
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The synthesis of compounds a and b are
2021-06-15
The synthesis of compounds 7a and 7b are outlined in Scheme 2. Compound 5 was obtained by di-tert-butyl pyrocarbonate protection of tnf alpha inhibitor 4a. Then, compounds 6a and 6b were obtained by amination of the fluoride with a morpholino and dimethylamine, respectively. Target compounds 7a and
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br Concluding remark br Acknowledgements br Detection and
2021-06-15
Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human opioid receptors daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cance
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Overall the DDR kinase domain has a typical kinase
2021-06-15
Overall, the DDR1 kinase domain has a typical kinase domain structure and adequate sequence and/or structure similarity with other kinase domains, as shown in Fig. 2, which allow homology modeling of the active and inactive conformations. In addition to conformational changes to the activation loop
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br Results and discussion br Conclusion Analogues of
2021-06-15
Results and discussion Conclusion Analogues of 1,2,4-triazole and 1,3,4-oxadiazole have been designed, synthesized and characterized. To avoid late stage failure, it is important to study the preliminary pharmacokinetic parameters. The results of pharmacokinetic data suggested that, all molecu
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The discoidin domain receptors DDR and DDR are
2021-06-15
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases (RTKs) that are stimulated by collagen in the extracellular matrix (ECM). Unlike most other RTKs, they form ligand-independent stable dimers that are non-covalently linked. This ECM activation induces receptor phosphorylati
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