• Mother rats acutely treated with quinpirole and

  2021-05-31

  

  Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha

• Although BPA has been proven to cause many health issues

  2021-05-28

  

  Although BPA has been proven to cause many health issues such as obesity and neurological toxicity (Rubin, 2011), the effects and mechanisms of BPA on the human tumorigenesis and cancer development are still not well illustrated. In the present study, we found that 10 to 10M BPA significantly promot

• SC-9 Introduction Activation of epidermal growth

  2021-05-28

  

  Introduction Activation of epidermal growth factor receptor (EGFR)-receptor tyrosine kinases (RTKs) is a key factor in the progression of non-small cell lung cancer (NSCLC). EGFR-RTKs cause proliferation, invasion, metastasis, and angiogenesis, as well as suppress apoptosis, in lung adenocarcinoma

• br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia

  2021-05-28

  

  Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin

• The strand domain swap in the UbV XR dimer appears

  2021-05-28

  

  The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2

• BRCC is the catalytic subunit responsible

  2021-05-28

  

  BRCC36 is the catalytic subunit responsible for the majority of K63-Ub-specific DUB activity in the cytoplasm and in the nucleus as part of two distinct macromolecular assemblies characterized by the presence of either of the MPN– pseudo DUB proteins KIAA0157 or Abraxas (Cooper et al., 2009, Dong et

• Elevated DPP activity has been strongly

  2021-05-28

  

  Elevated DPP-4 activity has been strongly associated with diabetes mellitus, IR (Röhrborn et al., 2015), metabolic syndrome (Lamers et al., 2011) and inflammation (Zhong et al., 2015). However, report has it that GC exposure increases DPP-4activity in thymocyte homogenates (Kraml et al., 2003) but t

• DA neurons are capable of somatodendritic and

  2021-05-28

  

  DA neurons are capable of somatodendritic and axonal DA release, which may occur at synapses, as well as non-synaptic or asynaptic sites (Trudeau et al., 2014). DA may also be released at different timescales and in response to different DA neuron firing patterns (Grace et al., 2007). Furthermore, s

• As shown in Fig there are two mechanisms for

  2021-05-28

  

  As shown in Fig. 9, there are two mechanisms for the removal of the Va-acyl group from PC to make it available for incorporation into TAG with DGATs' acting at the final acylation step. ①: Transfer of Va from PC to the acyl-CoA pool. This process can be driven by the reverse action of acyl- CoA:lyso

• In this review focusing on

  2021-05-28

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic W146 oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO2 reduct

• Our data show a site specific interaction

  2021-05-28

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• Since Slaughter s proposal of

  2021-05-28

  

  Since Slaughter’s proposal of a genetic field defect concept for the explanation of the local relapse occurrence, much evidence has accumulated for its confirmation. The last ten years brought evidence that the genetic changes in the field are frequently accompanied by epigenetic aberrations. The ep

• Acknowledgment This work was supported by

  2021-05-28

  

  Acknowledgment This work was supported by the Swedish Research Council, the Knut and Alice Wallenberg Foundation, the Göran Gustafsson Foundation, the Swedish Pain Relief Foundation, the Torsten Söderbergs Stiftelse, the Swedish Children's Cancer Foundation, and the Swedish Cancer Society. The h

• One of the most frequent

  2021-05-28

  

  One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are Chlorothiazide regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respectiv

• The mechanism by which these HIV PIs impair

  2021-05-27

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty Terbutaline Sulfate translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular me

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